Hyperclownism

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Hyperclownism is a genetic medical disorder caused by an error in the fourth gene of chromosome 13. This gene codes for proteins connected to proper brain development (specifically decision-making centers of the brain), skin pigmentation, hair color, nose size, color recognition, and sensitivity of the skin to touch. The error causes the proteins to fold incorrectly upon formation. The regular protein folding configurations are replaced by folding shapes resembling animals, such as horses, giraffes, and dinosaurs. These are referred to as "balloon animal" protein folds. Those suffering from hyperclownism are generally stricken with total facial albinism highlighted with unusually bright colored pigmentation defects around the mouth. They exhibit hyperclownic hair (brightly colored hair which is unusually fine and thin). Many but not all people with hyperclownism have large, red, bulbous noses. People stricken with hyperclownism, frequently referred to by the pejorative "clowns" have been forced throughout history to perform as side show attractions and entertainers, due to their unusual appearances and strange behaviors.

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